Search for: All records

Training students in interdisciplinary thinking is critical for the future of scientific discovery and problem-solving more generally. Therefore, students must have early opportunities to grapple with knowns and unknowns at the frontiers of interdisciplinary inquiry. Neuroimmunology challenges students to think at the intersection of two rapidly evolving fields, neuroscience and immunology. As these disciplines focus on complex systems, their intersection represents a unique opportunity for students to witness the nature and process of interdisciplinary collaboration and synthesis. However, the fast pace of research and specialized knowledge in both disciplines present challenges for instructors interested in teaching the subject to undergraduate students. In this article, we share and describe a curriculum developed using a backward-design approach to analyze core concepts in both neuroscience and immunology, which were articulated by disciplinary experts in collaboration with their respective education communities. We determine overlaps between these conceptual frameworks, identify key prerequisite knowledge, and suggest example activities to introduce neuroimmunology to undergraduate students. This curriculum may be used for an entire course, or modified into shorter units that instructors can use within diverse educational contexts. We hope that this effort will encourage instructors to adopt neuroimmunology into their curricula, provide a roadmap to forge other such interdisciplinary educational collaborations, and prepare students to develop creative solutions to current and future societal problems. 

Synopsis Across the animal kingdom, the ability to produce communication signals appropriate to social encounters is essential, but how these behaviors are selected and adjusted in a context-dependent manner are poorly understood. This question can be addressed on many levels, including sensory processing by peripheral organs and the central nervous system, sensorimotor integration in decision-making brain regions, and motor circuit activation and modulation. Because neuromodulator systems act at each of these levels, they are a useful lens through which to explore the mechanisms underlying complex patterns of communication. It has been clear for decades that understanding the logic of input–output decision making by the nervous system requires far more than simply identifying the connections linking sensory organs to motor circuits; this is due in part to the fact that neuromodulators can promote distinct and temporally dynamic responses to similar signals. We focus on the vocal circuit dynamics of Xenopus frogs, and describe complementary examples from diverse vertebrate communication systems. While much remains to be discovered about how neuromodulators direct flexibility in communication behaviors, these examples illustrate that several neuromodulators can act upon the same circuit at multiple levels of control, and that the functional consequence of neuromodulation can depend on species-specific factors as well as dynamic organismal characteristics like internal state.